Principal Investigator
Yu Ye
Principal InvestigatorSenior Lecturer in Molecular Neuroscience
at Imperial College London
MRC-LMB, University of Cambridge, Ph.D
Imperial College London, BSc Biochemistry/Biotechnology Profile: Imperial College London - UK DRI - Researcher Interview
Email: yu.ye1@imperial.ac.uk
Bio: I grew up in a Nordic university town and completed a bilingual International Baccalaureate at the local Cathedral School. After undergraduate studies at Imperial, I continued with a PhD at St John's College, University of Cambridge. My training in David Komander's lab at MRC Laboratory of Molecular Biology combined structural biology with biophysical techniques to study molecular details underlying regulation of the ubiquitin-proteasome system (UPS). Following this, I was fortunate to secure funding first through a Henslow Junior Research Fellowship and then a Sir Henry Wellcome Research Fellowship to study the UPS and protein aggregation with super-resolution imaging techniques. Working between David Klenerman's group at Cambridge and Daniel Finley's group at Harvard, my research focused on exploiting the UPS system to remove protein aggregates. During this time, I also served as a Fellow and later also Director of Studies in Natural Sciences at the beautiful Selwyn College, Cambridge, where I still hold many fond memories.
My group at the Department of Brain Sciences at Imperial College London continues to study the interplay between UPS, protein aggregation, proteostasis and neurodegeneration.
Although in science it may be customary to refer the team by the PI's last name, this Lab is really about the team. Members past and present, their contribution and legacy. Their skills, technical and intellectual input, their protocols, codes, cell lines validated. Their presence and devotion shape the lab Ethos, our culture, and our Mission Statement. And as the lab coach, I'm proud to support everyone in the lab in reaching their full potential.
Research staff
Michael Morten
Research Associate in BiophysicsUniversity of St Andrews, PhD Biology
University of Oxford, MChem
Email: m.morten@imperial.ac.uk
Bio: I currently work on developing novel techniques to image aggregates in cells and tissues. I have previously used single-molecule TIRF and confocal microscopes in my PhD research (University of St Andrews) and postdoc projects (University of Glasgow and NYU School of Medicine), and I am now in the process of building a new light sheet microscope here in the Ye Group at the UK DRI at Imperial.
Liina Sirvio
Research Associate in BiochemistryImperial College London, PhD Biochemistry
Imperial College London, MRes Molecular and Cellular Biosciences
King's College London, BSc Biochemistry
Email: l.sirvio18@imperial.ac.uk
Bio: I was a PhD student at the UK Dementia Research Institute investigating the role of post-translational modifications of amyloid proteins in the pathogenesis of Alzheimer’s and Parkinson’s diseases. Prior to starting my PhD, I completed my BSc in Biochemistry at KCL, MRes at Imperial College London, and worked as a research technician in the Ultanir Lab at The Francis Crick Institute.
Selene Lee
Research Associate in NeuropathologyUniversity of Oxford, PhD Clinical Neurosciences
University College London, MRes Translational Neurosciences
Imperial College London, BSc Biochemistry
Email: seoyun.lee@imperial.ac.uk
Bio: I was a PhD student in Laura Parkkinen's lab leading a project to characterise different alpha-synucleinopathies using "seed amplification assay" and mass spectrometry. I now aspire to further include tauopathies in my portfolio of molecular characterisation, determining the specific profiles of protein aggregates using advanced biophysical and biochemical methods in the Ye lab. I am excited to return to London and my alma mater to further build my career and progress!
Chiao-Yin Lee
Research Associate in Biochemical NeuroscienceUniversity College London, PhD Neurodegeneration
Imperial College London, MRes Molecular and Cellular Biosciences
Imperial College London, BSc Biochemistry
Email: chiao.lee15@imperial.ac.uk
Bio: I was a PhD student in Tony Schapira’s lab studying the molecular and cellular interactions between LRRK2 and GBA1 in Parkinson’s disease using iPSC and mouse models. I have now returned to Imperial to start a collaborative project with Eisai, focusing on targeting proteostasis systems in synucleinopathy models with an emphasis on multidisciplinary translational research.
Sanjali Shirish
Research Technician in Cellular NeuroscienceImperial College London, MSc Immunology
University of Edinburgh, BSc Immunology
PhD candidates
Matilda Burridge
PhD StudentImperial College London, BSc Biochemistry with French Profile: Imperial College London
Email: matilda.burridge18@imperial.ac.uk
Bio:Matilda, or Mattie, is funded by the prestigous President's PhD Scholarship, awarded whilst she was finishing her BSc degree. Mattie's project in the lab is to study the role of immunoprotasomes in tauopathies. Prior to starting her PhD, Mattie did research in the Ye lab as a UROP student to develop cell lines for protein aggregation assays.
Katarina Gregorovicsova
PhD Student (Co-supervisor: Michael Johnson)Imperial College London, MSc Translational Neuroscience
Durham University, BSc Natural Sciences
Email: katarina.gregorovicsova22@imperial.ac.uk
Bio:I am completing the first year of my PhD journey in the Ye lab, working on a collaborative project to validate a potential drug target in Parkinson's disease cell models. This project is funded by Parkinson's UK. Before my PhD, I earned my master's in Translational Neuroscience at Imperial College London and worked as a research technician in the UK Dementia Research Institute for a year.
Dorcas Cheung
PhD Student/Research AssistantUniversity College London, MSc Dementia Neuroscience
University of Manchester, BSc Biomedical Science
Email: t.cheung@imperial.ac.uk
Bio:I am PhD student/ research assistant between the Ye and Jackson lab. I previously worked on several functional genetic studies under the Matthews lab at the UK DRI focusing on multiomic techniques and analysis. I am looking forward to starting my project on investigating synaptic proteostasis in Parkinson’s disease dementia.
