Publications

$equal contribution, *corresponding author

2022

toxicity profiles

16. Morten M, Sirvio L, Rupawala H, Mee Hayes E, Franco Budia, Radulescu C, Rupawala H, Ying L, Barnes SJ, Muga A, YE Y.*
 Quantitative super-resolution imaging of pathological aggregates reveals distinct toxicity profiles in different synucleinopathies (2022)
PROCCEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA        Explained in plain English in this UK DRI News Article or on this Kudos page.
Winner of UK DRI Publication Prize 2022 which "highlights exceptional scientific discovery or progress in methodology".

phosphotau

15. Meng J.X., Zhang Y., Saman D., Haider A.M., De S., Sang J.C., Brown K., Jiang K., Humphrey J., Julian L., Hidari E., Lee S.F., Balmus G., Floto R.A., Bryant C., Benesch J., YE Y., Klenerman D.
 Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses  (2022)
NATURE COMMUNICATIONS

TAAD review

14. Mee Hayes E., Sirvio L., YE Y.*
 A Potential Mechanism for Targeting Aggregates With Proteasomes and Disaggregases in Liquid Droplets  (2022)
FRONTIERS IN AGING NEUROSCIENCE
Review

2021

Paper

13. Li, B., Ponjavic, A., Chen, W. H., Hopkins, L., Hughes, C., YE Y., Bryant, C. and Klenerman, D.
 Single-Molecule Light-Sheet Microscopy with Local Nanopipette Delivery  (2021)
ANALYTICAL CHEMISTRY

2020

12. Zuo, Y., Chong, B. K., Jiang, K., Finley, D., Klenerman, D. and YE Y.*
 A general in vitro assay to study enzymatic activities of the ubiquitin system  (2020)
BIOCHEMISTRY

11. YE Y.*, Klenerman, D. and Finley, D.
 N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme  (2020)
JOURNAL OF MOLECULAR BIOLOGY

2019

10. Cliffe, R.$, Sang, J. C., Kundel, F., Finley, D., Klenerman, D. and YE Y.*$
 Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme  (2019)
CELL REPORTS

2018

9. Ponjavic, A., YE Y., Laue, E., Lee, S. F. and Klenerman, D.
 Sensitive light-sheet microscopy in multiwell plates using an AFM cantilever  (2018)
BIOMEDICAL OPTICS EXPRESS

8. Zhang, Y., Lippert, A. H., Lee, J. E., Carr, A. R., Ponjavic, A., Lee, S. F., Finley, D., and Klenerman, D. and YE Y.*
  Membrane potential regulates the dynamic localisation of mammalian proteasomes  (2018)
bioRxiv

2016

7. Iljina, M., Tosatto, L., Choi, M. L., Sang, J. C., YE Y., Hughes, C. D., Bryant, C. E., Gandhi, S. and Klenerman, D. 2016
 Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein  (2016)
SCIENTIFIC REPORTS

2012

6. YE Y., Blaser, G., Horrocks, M. H., Ruedas-Rama, M. J., Ibrahim, S., Zhukov, A. A., Orte, A., Klenerman, D., Jackson, S. E. and Komander, D.
 Ubiquitin chain conformation regulates recognition and activity of interacting proteins  (2012)
NATURE       
Featured in Nature Structural and Molecular Biology Jan 2013 .

5. Agromayor, M., Soler, N., Caballe, A., Kueck, T., Freund, S. M., Allen, M. D., Bycroft, M., Perisic, O., YE Y., McDonald, B., Scheel, H., Hofmann, K., Neil, S. J. D., Martin-Serrano, J. and Williams, R. L.
 The UBAP1 Subunit of ESCRT-I Interacts with Ubiquitin via a SOUBA Domain  (2012)
STRUCTURE

2011

4. YE Y., Akutsu, M., Reyes-Turcu, F., Enchev, R. I., Wilkinson, K. D. and Komander, D.
 Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21 (2011)
EMBO REPORTS

3. Akutsu, M., YE Y., Virdee, S., Chin, J. W. and Komander, D.
 Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains (2011)
PROCCEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA

2010

2. Virdee, S., YE Y., Nguyen, D. P., Komander, D. and Chin, J. W.
 Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase (2010)
NATURE CHEMICAL BIOLOGY

2009

1. YE Y.$, Scheel, H.$, Hofmann, K. and Komander, D.
 Dissection of USP catalytic domains reveals five common insertion points (2009)
MOLECULAR BIOSYSTEMS

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